Multi-scale electrophysiology modeling: from atom to organ

Multi-scale electrophysiology modeling: from atom to organ

In excitable cells, the molecular motions of ion channels are linked to the whole cell physiology via the transmem-brane potential (V m). To examine such events at the cellular level, we recently proposed a model that links the molecular dynamics (MD) and electrostatics of the slow delayed rectifier K + channel (I Ks) to the cell and tissue electrophysiology (Silva et al., 2009). Although the d...

Perspectives on: Molecular dynamics and computational methods Multi-scale electrophysiology modeling: from atom to organ

A Multi-Scale Approach to Airway Hyperresponsiveness: From Molecule to Organ

Airway hyperresponsiveness (AHR), a characteristic of asthma that involves an excessive reduction in airway caliber, is a complex mechanism reflecting multiple processes that manifest over a large range of length and time scales. At one extreme, molecular interactions determine the force generated by airway smooth muscle (ASM). At the other, the spatially distributed constriction of the branchi...

multi-organ failure due to paraquat poisoning

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Multi-Scale Characean Experimental System: From Electrophysiology of Membrane Transporters to Cell-to-Cell Connectivity, Cytoplasmic Streaming and Auxin Metabolism

The morphology of characean algae could be mistaken for a higher plant: stem-like axes with leaf-like branchlets anchored in the soil by root-like rhizoids. However, all of these structures are made up of giant multinucleate cells separated by multicellular nodal complexes. The excised internodal cells survive long enough for the nodes to give rise to new thallus. The size of the internodes and...